Howard Moon and Vince Noir have adventures whilst working at a zoo, with the shaman Naboo the Enigma and his familiar, Bollo the Gorilla. Along with their boss, Bob Fossil and the zoo-owner, Dixon Bainbridge. The Mighty Boosh's first series was originally broadcast between 18 May 2004 and 6 July 2004. A DVD of the series was released on 29 August 2005 in Region 2. Series 1 began to air in America on Adult Swim from 29 March 2009.

Howard Moon and Vince Noir have adventures whilst living in their flat, which they share with Naboo and Bollo. The Mighty Boosh's second series was originally broadcast between 25 July 2005 and 30 August 2005. The series features five main cast members: Julian Barratt, Noel Fielding, Rich Fulcher, Michael Fielding and Dave Brown. A DVD of the series was released on 13 February 2006 in Region 2, and on 21 July 2009 in Region 1. The DVD also included the pilot episode for 'The Boosh', made in 2003, before the first series. The episode was titled 'Tundra' and was remade for the first series.

Howard Moon and Vince Noir have adventures whilst running Naboo’s second-hand shop. The Mighty Boosh's third series was originally broadcast between 15 November 2007 and 20 December 2007. The series features five main cast members; Julian Barratt, Noel Fielding, Rich Fulcher, Michael Fielding and Dave Brown. A DVD of the series was released on 11 February 2008 in Region 2 and 7 August in Region 4.