Ish must protect one or more NFL team's Core shards from the villainous alien cyborg Sudden Death every Sunday while trying not to be caught by his mom. He protects the shards with the help of OT and the Rusherz.

One year after the defeat of Sudden Death, Ish has moved from San Diego to Canton, Ohio, and soon finds his role as a Guardian expanded with new powers and the emergence of the villainous Wild Card. With the aid of his old friend Ash and new friends Troy, Tua, Marty, and later, Ricky, Ish must protect the 32 Megacores of the NFL from Wild Card, while also diving into the villain's mysterious past.

Wild Card has been defeated, but at the cost of Ish losing his Guardian powers. Having been the first Guardian, Ish is hit hard by this loss, while a newly resurfaced Sudden Death looks to continue where he left off, with three robotic aliens called Anticorians, who have had a sworn rivalry with the Rusherz, and perhaps with the help of a now vulnerable Ish. Ish, however soon regains his powers, and he and his friends have theirs upgraded for the re-match against Sudden Death and his allies the Anti-Corians, as well as the returns of Wild Card and Drop Kick.